HB Yana Ƙirƙirar Sabon Tsarin Don Adana Samfurin Halittu a ICL

Kwalejin Imperial ta London (ICL) tana kan gaba a binciken kimiyya kuma, ta hanyar Sashen Kula da Immunology da Kumburi da Sashen Kimiyyar Kwakwalwa, bincikensa ya bambanta daga rheumatology da ilimin jini zuwa hauka, cutar Parkinson da kansar kwakwalwa. Sarrafa irin wannan bincike daban-daban yana buƙatar kayan aiki na zamani, musamman don adana samfuran halitta masu mahimmanci. Neil Galloway Phillipps, Babban Manajan Lab na sassan biyu, ya gane buƙatar ingantaccen bayani mai dorewa kuma mai dorewa.

ICL Bukatu

1.Babban ƙarfi, ƙarfafa tsarin ajiyar ruwa nitrogen

2.Rage amfani da nitrogen da farashin aiki

3.Inganta samfurin tsaro da bin ka'ida

4.Mafi aminci da ingantaccen isa ga masu bincike

5.Magani mai dorewa don tallafawa ayyukan kore

Kalubalen

Sashen ICL na Immunology a baya ya dogara da 13 daban-daban na ruwa nitrogen (LN₂) tankuna don adana samfuran gwaji na asibiti, sel tauraron dan adam da al'adun sel na farko. Wannan rarrabuwar tsarin yana ɗaukar lokaci don kiyayewa, yana buƙatar kulawa akai-akai da sake cikawa.

"Cika tankuna 13 ya ɗauki lokaci mai tsawo, kuma lura da komai yana ƙara zama da wahala," in ji Neil. "Kalubale ne na dabaru, kuma muna buƙatar ingantacciyar hanya don sarrafa ma'ajiyar mu."

Kudin kula da tankuna da yawa wani abin damuwa ne. LN₂amfani ya yi yawa, yana ba da gudummawa ga hauhawar farashin aiki. A lokaci guda, tasirin muhalli akai-akai na isar da iskar nitrogen ya yi hannun riga da jajircewar dakin binciken don dorewa. "Mun kasance muna aiki don samun kyaututtukan dorewa iri-iri, kuma mun san cewa rage yawan amfani da sinadarin nitrogen zai kawo babban canji," in ji Neil.

Tsaro da bin ka'ida su ma manyan abubuwan da suka sa a gaba. Tare da tankuna masu yawa da aka bazu a wurare daban-daban, samun damar bin diddigin da kiyaye bayanan zamani ya kasance mai rikitarwa. Neil ya kara da cewa "Yana da mahimmanci mu san ainihin wanda ke samun damar yin amfani da samfuran, kuma an adana komai daidai daidai da ka'idojin Hukumar Kula da Nama (HTA). "Tsohon tsarin mu bai yi sauƙi ba."

Maganin

ICL ta riga tana da kewayon kayan aiki daga Haier Biomedical - ma'ajin sanyi mai faɗi, kabad ɗin aminci na halitta, CO₂incubators da centrifuges - haɓaka dogara ga mafita na kamfanin.

Don haka Neil da tawagarsa sun tunkari Haier Biomedical don taimakawa wajen magance waɗannan sabbin ƙalubalen, tare da shigar da babban ƙarfin CryoBio 43 LN.₂bankin biobank don haɗa dukkan tankuna 13 na tsaye zuwa tsarin ingantaccen inganci guda ɗaya. Canjin ya kasance ba tare da matsala ba, tare da ƙungiyar Haier da ke kula da shigarwa da horar da ma'aikatan lab. Sabon tsarin ya shiga cikin LN data kasance₂makaman aiki tare da ƙananan gyare-gyare. Tare da sabon tsarin da aka yi, samfurin ajiya da sarrafawa sun zama mafi inganci. "Daya daga cikin fa'idodin da ba mu zato ba shine yawan sararin da muka samu," in ji Neil. "Tare da cire duk waɗannan tsoffin tankuna, yanzu muna da ƙarin daki a cikin lab don sauran kayan aiki."

A baya, duk lokacin da muka fitar da tarkace daga cikin tanki na ruwa-lokaci, zai kasance yana digo da nitrogen, wanda koyaushe abin damuwa ne.

Neil da tawagarsa sun sami tsarin da ya dace don amfani, tare da shirin horar da Haier yana ba su damar shiga cikin masu amfani da ƙarshen.

Wani fasalin da ba a zata ba amma maraba shine matakan da za'a iya dawo da su ta atomatik, wanda ke sauƙaƙa samun damar tanki. "Tare da tankunan da suka gabata, masu bincike sau da yawa sun ɗaga abubuwa gabaɗaya. Ko da yake sabon tanki ya fi tsayi, matakan da aka tura a tura maɓalli, ƙarawa ko cire samfurori da sauƙin sarrafawa, "in ji Neil.

Kiyaye samfurori masu mahimmanci

Samfuran da aka adana a cikin kayan aikin cryogenic na ICL suna da matukar amfani ga bincike mai gudana. Neil ya ce "Wasu samfuran da muke adanawa ba za su iya maye gurbinsu ba."

"Muna magana ne game da shirye-shiryen kwayar jinin jini daga cututtukan da ba kasafai ba, samfuran gwaji na asibiti, da sauran kayan da ke da mahimmanci don bincike. Waɗannan samfuran ba kawai ana amfani da su a cikin dakin gwaje-gwaje ba; ana raba su tare da masu haɗin gwiwa a duk faɗin duniya, suna mai da amincin su gabaɗaya. Amfanin waɗannan sel shine komai. Idan ba a adana su da kyau ba, binciken da suke goyan baya zai iya zama cikas ga tsarin da za mu iya dogara da shi. cikakken kwanciyar hankali za mu iya bincika bayanan zafin jiki a kowane lokaci, kuma idan an taɓa bincikar mu, za mu iya nuna gaba gaɗi cewa an adana komai daidai.

 Inganta dorewa da ƙimar farashi

Gabatar da sabon bankin biobank ya rage yawan amfani da sinadarin nitrogen a dakin gwaje-gwaje, inda ya rage sau goma. "Kowace tsoffin tankunan da ke rike da lita 125, don haka karfafa su ya yi matukar tasiri," in ji Neil. "Yanzu muna amfani da wani kaso na nitrogen da muka yi a baya, kuma wannan babbar nasara ce ta fannin kudi da muhalli."

Tare da ƙarancin isar da iskar nitrogen da ake buƙata, an rage fitar da iskar carbon, yana tallafawa maƙasudin dorewa na lab. Neil ya kara da cewa, "Ba wai kawai game da nitrogen da kanta ba." "Samun karancin isar da kayayyaki yana nufin karancin manyan motoci a kan hanya, da karancin makamashi da ake amfani da su wajen samar da sinadarin nitrogen tun da farko." Waɗannan haɓakawa sun kasance masu mahimmanci har Imperial ya karɓi kyaututtukan dorewa daga LEAF da My Green Lab don sanin ƙoƙarinsa.

Kammalawa

Haier Biomedical's cryogenic biobank ya canza ikon ajiyar ICL, inganta inganci, aminci da dorewa tare da rage farashi sosai. Tare da ingantacciyar yarda, ingantaccen samfurin tsaro da rage tasirin muhalli, haɓakawa ya kasance babban nasara.

Sakamakon Ayyukan

1.LN₂rage amfani da kashi 90%, rage farashin da fitar da hayaki

2.Ingantacciyar bin diddigin samfurin da kuma yarda da HTA

3.Ma'ajiyar yanayin tururi mai aminci ga masu bincike

4.Ƙara ƙarfin ajiya a cikin tsarin guda ɗaya

5.Ganewa ta hanyar kyaututtuka masu dorewa