HB Ta Ƙirƙiri Sabuwar Tsarin Ajiye Samfurin Halittu a ICL

Kwalejin Imperial ta Landan (ICL) tana kan gaba a binciken kimiyya, kuma ta hanyar Sashen Rigakafi da Kumburi da Sashen Kimiyyar Kwakwalwa, bincikenta ya shafi ilimin cututtukan rheumatology da hematology zuwa ciwon hauka, cutar Parkinson da ciwon daji na kwakwalwa. Gudanar da irin waɗannan bincike daban-daban yana buƙatar kayan aiki na zamani, musamman don adana samfuran halittu masu mahimmanci. Neil Galloway Phillipps, Babban Manajan Lab na sassan biyu, ya fahimci buƙatar samun mafita mai inganci da dorewa ta adana abubuwa masu guba.

Bukatun ICL

1.Tsarin ajiyar ruwa mai yawan ƙarfi, mai haɗakar nitrogen

2.Rage amfani da nitrogen da farashin aiki

3.Inganta tsaro da bin ƙa'idodi na samfuri

4.Samun damar shiga mafi aminci kuma mafi inganci ga masu bincike

5.Magani mai ɗorewa don tallafawa shirye-shiryen kore

Kalubalen da ke tattare da hakan

Sashen Immunology na ICL a da ya dogara ne akan nau'ikan nitrogen guda 13 daban-daban (LN)₂) tankuna don adana samfuran gwaji na asibiti, ƙwayoyin tauraron ɗan adam da kuma al'adun ƙwayoyin halitta na farko. Wannan tsarin da ya wargaje ya ɗauki lokaci mai tsawo don kulawa, yana buƙatar kulawa akai-akai da sake cikawa.

"Cika tankuna 13 ya ɗauki lokaci mai tsawo, kuma bin diddigin komai yana ƙara zama da wahala," in ji Neil. "Kalubalen dabaru ne, kuma muna buƙatar hanya mafi inganci don sarrafa ajiyar mu."

Kudin kula da tankuna da yawa wani abin damuwa ne.₂Yawan amfani da shi ya yi yawa, wanda hakan ke haifar da hauhawar farashin aiki. A lokaci guda kuma, tasirin muhalli na isar da sinadarin nitrogen akai-akai ya saba wa jajircewar dakin gwaje-gwaje kan dorewa. "Mun yi aiki don samun kyaututtuka daban-daban na dorewa, kuma mun san cewa rage amfani da sinadarin nitrogen zai yi babban canji," in ji Neil.

Tsaro da bin ƙa'idodi suma su ne manyan abubuwan da suka fi muhimmanci. Ganin cewa tankuna da yawa sun bazu a wurare daban-daban, bin diddigin hanyoyin shiga da kuma kiyaye bayanan da suka dace ya kasance mai sarkakiya. "Yana da mahimmanci mu san ainihin wanda ke samun damar yin amfani da samfuran, kuma a adana komai daidai da ƙa'idodin Hukumar Kula da Tarin Dan Adam (HTA). "Tsohon tsarinmu bai sauƙaƙa hakan ba."

Maganin

ICL ta riga ta mallaki kayan aiki iri-iri daga Haier Biomedical - waɗanda suka haɗa da wurin ajiye sanyi, kabad ɗin aminci na halittu, CO₂injinan incubator da centrifuges – haɓaka amincewa da mafita na kamfanin.

Saboda haka Neil da tawagarsa sun nemi taimakon Haier Biomedical don magance waɗannan sabbin ƙalubalen, inda suka girka babban jirgin CryoBio 43 LN mai ɗaukar kaya mai yawa.₂biobank ya haɗa dukkan tankunan da ke tsaye guda 13 zuwa tsarin aiki guda ɗaya mai inganci. Sauyin ya kasance cikin sauƙi, tare da ƙungiyar Haier da ke kula da shigarwa da horar da ma'aikatan dakin gwaje-gwaje. Sabon tsarin ya shiga cikin LN ɗin da ke akwai₂wurin aiki tare da ƙananan gyare-gyare kawai. Da sabon tsarin da aka gina, ajiyar samfura da gudanarwa sun zama mafi inganci sosai. "Ɗaya daga cikin fa'idodin da ba a zata ba shine yawan sararin da muka samu," in ji Neil. "Bayan an cire duk waɗannan tsoffin tankuna, yanzu muna da ƙarin sarari a dakin gwaje-gwaje don sauran kayan aiki."

Sauya zuwa ajiyar lokaci-lokaci na tururi ya inganta aminci da sauƙin amfani. "A da, duk lokacin da muka cire rack daga tankin ruwa, yana diga da nitrogen, wanda koyaushe abin damuwa ne ga tsaro. Yanzu, tare da ajiyar lokaci-lokaci na tururi, ya fi tsabta kuma mafi aminci don ɗaukar samfura. Tsarin damar biometric ya kuma ƙarfafa tsaro da bin ƙa'idodi domin za mu iya bin diddigin wanda ya shiga tsarin da kuma lokacin da."

Neil da tawagarsa sun ga tsarin ya zama mai sauƙin amfani, tare da shirin horarwa na Haier wanda ya ba su damar shigar da masu amfani da shi cikin sauri.

Wani abin da ba a zata ba amma mai maraba shi ne matakan da za a iya ja da baya ta atomatik, wanda hakan ke sauƙaƙa shiga tankin. "Da tankunan da suka gabata, masu bincike kan ɗauki kayayyaki a hankali. Ko da yake sabon tankin ya fi tsayi, matakan suna aiki ne kawai da danna maɓalli, wanda hakan ke sa ƙara ko cire samfuran su fi sauƙi a sarrafa su," in ji Neil.

Adana samfura masu mahimmanci

Samfuran da aka adana a cibiyar ICL mai cike da sinadarai masu guba suna da matuƙar amfani ga ci gaba da bincike. "Wasu daga cikin samfuran da muke adanawa ba za a iya maye gurbinsu ba kwata-kwata," in ji Neil.

"Muna magana ne game da shirye-shiryen ƙwayoyin jinin fararen fata daga cututtuka masu wuya, samfuran gwaji na asibiti, da sauran kayan da suke da mahimmanci don bincike. Ba wai kawai ana amfani da waɗannan samfuran a cikin dakin gwaje-gwaje ba; ana raba su tare da masu haɗin gwiwa a duk faɗin duniya, wanda hakan ke sa amincinsu ya zama da matuƙar muhimmanci. Rayuwar waɗannan ƙwayoyin shine komai. Idan ba a adana su yadda ya kamata ba, binciken da suke tallafawa zai iya yin illa. Shi ya sa muke buƙatar ajiyar sanyi mai inganci wanda za mu iya amincewa da shi. Tare da tsarin Haier, muna da cikakkiyar kwanciyar hankali. Za mu iya duba yanayin zafin jiki a kowane lokaci, kuma idan an taɓa duba mu, za mu iya nuna da tabbaci cewa an adana komai daidai."

 Inganta dorewa da ingancin farashi

Gabatar da sabon bankin biobank ya rage yawan amfani da sinadarin nitrogen a dakin gwaje-gwaje sosai, inda ya rage shi ninki goma. "Kowanne daga cikin tsoffin tankunan ya ɗauki kimanin lita 125, don haka haɗa su ya kawo babban canji," Neil ya bayyana. "Yanzu muna amfani da wani ɓangare na sinadarin nitrogen da muka yi a baya, kuma wannan babbar nasara ce ta kuɗi da muhalli."

Da yake ana buƙatar ƙarancin isar da sinadarin nitrogen, an rage fitar da hayakin carbon, wanda hakan ke tallafawa manufofin dorewar dakin gwaje-gwajen. Neil ya ƙara da cewa, "Ba wai kawai game da sinadarin nitrogen ba ne." "Samun ƙarancin isar da kayayyaki yana nufin ƙarancin manyan motoci a kan hanya, kuma ƙarancin makamashi da ake amfani da shi don samar da sinadarin nitrogen tun farko." Waɗannan ci gaban sun yi matuƙar muhimmanci har Imperial ta sami kyaututtukan dorewa daga LEAF da My Green Lab don girmama ƙoƙarinta.

Kammalawa

Bankin biomedical mai suna cryogenic biobank ya sauya ƙarfin ajiyar ICL, yana inganta inganci, aminci da dorewa yayin da yake rage farashi sosai. Tare da ingantaccen bin ƙa'idodi, haɓaka tsaro na samfura da rage tasirin muhalli, haɓakawa ya kasance babban nasara.

Sakamakon Aiki

1.LN₂rage amfani da kashi 90%, rage farashi da hayakin da ke gurbata muhalli

2.Ingancin bin diddigin samfura da bin ƙa'idodin HTA

3.Ajiyar tururi mafi aminci ga masu bincike

4.Ƙara ƙarfin ajiya a cikin tsarin guda ɗaya

5.Amincewa ta hanyar kyaututtukan dorewa